c-Mer Tyrosine Kinase

A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.

Also Known As:

MERTK; c-Mer Proto-Oncogene Tyrosine Kinase; Kinase, c-Mer Tyrosine; Tyrosine Kinase, c-Mer; c Mer Proto Oncogene Tyrosine Kinase; c Mer Tyrosine Kinase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Receptor Protein-Tyrosine Kinases: 5999
        c-Mer Tyrosine Kinase: 419
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Receptor Protein-Tyrosine Kinases: 5999
        c-Mer Tyrosine Kinase: 419
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Receptor Protein-Tyrosine Kinases: 5999
        c-Mer Tyrosine Kinase: 419
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Proto-Oncogene Proteins: 7
        c-Mer Tyrosine Kinase: 419

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